In the mid-XVIII century, there was a wooden bridge here. In 1788, during the construction of granite embankments on the Fontanka River, the bridge was rebuilt in stone. It was one of the seven tower bridges built according to the standard design for bridges across the Fontanka. According to the General Plan for the Reconstruction of the Fontanka River, seven bridges were built from 1782 to 1788: Simeonovsky, Anichkov, Chernyshev, Obukhovsky, Izmailovsky, Semenovsky and Kalinkin. The bridges were erected according to a standard design developed by the French architect Jean-Rodolphe Perronet. Like the other standard bridges on the Fontanka River, the Izmailovsky Bridge was a three-span stone structure with a wooden double-wing drawbridge in the center and stone arches on the sides. The bridge supports were stone and faced with granite. On the supports at the bottom are triangular granite ice-cutters, and at the top are four granite towers, in which the lifting mechanisms were located. The bridge was raised manually using chains.

In the second half of the XIX century, it became necessary to expand the Izmailovsky Bridge. In 1861, according to the design of the engineer, Staff Captain V.V. Dymman, the bridge was rebuilt with the elimination of the over-bridge towers and the replacement of the central wooden lifting span structure with a solid stone vault. The lateral symmetrical spans, covered with stone vaults and the characteristic shapes of the ice-cutters at the river supports were preserved. The roadway was widened and fenced with a new forged metal grating of a complex design, proposed by the architect A.I. Krakau.

By 2007, the bridge had fallen into disrepair, and the city authorities decided to close it for major repairs. The brickwork of the central span structure was strengthened, the granite arch and parapet were repaired, the waterproofing was restored, utility lines were relocated on the coastal sections, and the road surface was renewed. During the restoration work, a previously unknown engineering feature was discovered - iron cables-tensions fixing the stonework.

At the end of 2008, the Izmailovsky Bridge was opened for traffic.